DEVELOPMENTAL ONCOGENE LABORATORY

There is a strong correlation between solid tumor progression and poor patient survival. Many signaling pathways and molecular/cellular mechanisms that control normal tissue homeostasis and fibrosis are dysregulated in cancer. Our group aims to identify and understand factors that regulate cancer progression, and whether these factors may also control tissue repair and fibrosis.

Targeting SMAD-Dependent Signaling: Considerations in Epithelial and Mesenchymal Solid Tumors Runa et al. Pharmaceuticals (2024)

Multidimensional screening of pancreatic cancer spheroids reveals vulnerabilities in mitotic and cell-matrix adhesion signaling that associate with metastatic progression and decreased patient survival Aquino et al. BBRC (2024)

Patient-Derived Organoids as Therapy Screening Platforms in Cancer Patients Khorsandi et al. Advanced Healthcare Materials (2024)

Aqueous humor TGFβ and fibrillin-1 in Tsk mice reveal clues to POAG pathogenesis Tan et al. Scientific Reports (2024)