There is a strong correlation between solid tumor progression and poor patient survival. Many signaling pathways and molecular/cellular mechanisms that control normal tissue homeostasis are dysregulated in cancer. Our group aims to identify and understand factors that regulate cancer metastasis and therapy resistance, and whether these factors may also control tissue repair.
Fibrillin-1 mutant mouse captures defining features of human primary open glaucoma including anomalous aqueous humor TGF beta-2. Ko et al. Scientific Reports
A SNAI2-PEAK1-INHBA stromal axis drives progression and lapatinib resistance in HER2-positive breast cancer by supporting subpopulations of tumor cells positive for antiapoptotic and stress signaling markers. Hamalian et al. Oncogene
Secretomes from metastatic breast cancer cells, enriched for a prognostically unfavorable LCN2 axis, induce anti-inflammatory MSC actions and a tumor-supportive premetastatic lung. Meade et al. Oncotarget