There is a strong correlation between solid tumor progression and poor patient survival. Many signaling pathways and molecular/cellular mechanisms that control normal tissue homeostasis are dysregulated in cancer. Our group aims to identify and understand factors that regulate cancer metastasis and therapy resistance, and whether these factors may also control tissue repair.
Aqueous humor TGFβ and fibrillin-1 in Tsk mice reveal clues to POAG pathogenesis Tan et al. Scientific Reports (2024)
Multidimensional screening of pancreatic cancer spheroids reveals vulnerabilities in mitotic and cell-matrix adhesion signaling that associate with metastatic progression and decreased patient survival Aquino et al. BBRC (2024)
Gelatin methacryloyl and laponite bioink for 3D bioprinted organotypic tumor modeling Barros et al. Biofabrication (2023)
A SNAI2-PEAK1-INHBA stromal axis drives progression and lapatinib resistance in HER2-positive breast cancer by supporting subpopulations of tumor cells positive for antiapoptotic and stress signaling markers Hamalian et al. Oncogene (2021)